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Synergistic lethal effect between PI3K/mTOR inhibitor Voxtalisib and arsenic trioxide on human leukemic KG-1 cell line

Pin Wu¹, Hongying Chao², Ri Zhang¹, Suning Chen¹

¹Department of Hematology, The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of

Ministry of Health, Suzhou, Jiangsu 215006, China

²Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, China

zhangri2018@163.com or wupindoctor@163.com

Abstract: Myeloid/lymphoid neoplasms with FGFR1 rearrangement(also known as 8p11 myeloproliferative syndrome, EMS) is a distinct disease entity in the current WHO classification. These patients frequently (~80%) progress to acute myeloid leukemia (AML) and have a poor outcome with a 5-year survival rate of < 20%. To identify the potential treatment regimen on these patients, the four reagents (Idarubicin, arsenic trioxide, Voxtalisib and Ruxolitinib) were applied on KG-1 cells. Our results showed that the KG-1 cell line was resistant to  idarubicin. However, the dual PI3K/mTOR inhibitor Voxtalisib, rather than JAK1/2 inhibitor Ruxolitinib could be effectively against KG-1 cells. Arsenic trioxide(As2O3) combined with Voxtalisib synergistically inhibitted the viability of KG-1 cells. We also found that the combination treatment more significantly reduced the colony formation, induced apoptosis, decreased Bcl-2 expression, but increased caspase-3 expression as compared to the single drug treatment. Additionally, As2O3 enhanced the effect of Voxtalisib which decreased the phosphorylation of PI3K, AKT and mTOR. These data suggests that Voxtalisib in combination with As2O3 may provide a novel and efficacious therapy regimen for patients with EMS.

[Wu Pin, Chao Hongying, Zhang Ri, Chen Suning. Synergistic lethal effect between PI3K/mTOR inhibitor Voxtalisib and arsenic trioxide on human leukemic KG-1 cell line. Life Sci J 2023;20(11):1-8]. ISSN 1097-8135 (print); ISSN 2372-613X (online).http://www.lifesciencesite.com. 01.doi:10.7537/marslsj201123.01.

Key words: 8p11 myeloproliferative syndrome, Voxtalisib, Arsenic trioxide, KG-1 cells

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Analytical Assessment of Parsian bank customers' satisfaction levels of service quality using Servqual model

Hassan Darvish¹, Parizad Tilekoo2

1- Department of Public Administration, Payame Noor University, PO BOX 19395-3697,  Tehran, IRAN,

E-mail:dr.darvish43@yahoo.com

2-Department of Public Administration, Payame Noor University, PO BOX 19395-3697, Tehran, IRAN,

E-mail: tilekoo88@gmail.com

ABSTRACT: The purpose of this study is investigating the relation between levels of services quality and customers’ satisfaction. Population of this study includes customers of Parsian Bank. In this study, it has been used Servqual model for evaluating the customers’ satisfaction levels and for data analysis; there has been used Parametric T test. Results indicated that there is a significant difference between dimensions of study variables (i.e. tangible and physical dimensions, reliability, responsiveness, assurance and concordance) in the perceptual level and expectations.

[Hassan Darvish, Parizad Tilekoo. Analytical Assessment of Parsian bank customers' satisfaction levels of service quality using Servqual model. J Am Sci 2023;19(11):11-18]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org. 02. doi: 10.7537/marsjas191123.

Keywords: Validity, Assurance, Tangible, Empathy, Responsiveness

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OVERVIEW OF SPORTS INFRASRUCTURE AMONG GOVERNMENT AND PRIVATE SCHOOLS IN  KASHMIR VALLEY

AAJAZ AHMAD BHAT* SUHAIL YAQOOB BHAT**

Research scholar dr CV Raman University Kargi Road Kota Bilaspur.

Physical education teacher youth services and sports  department j & K.

Abstract: The reason for the review was to figure out the distinction in sports foundation among Government and private schools. To get to the Games foundation among both kind of organizations a data sheet was utilized which includes the inquiries of both the factors as the rundown of sports framework accessible and sports offices give by these establishments to sports individual. Results of the present study shows through average and percentage method that Private schools of Kashmir valley exists more sports infrastructure as compared to Government schools for the promotion of games and sports. It was hypothesized that Private schools of Kashmir valley may have more sports infrastructure availability and they provide more sports facility to sports person than Government schools. The outcomes were found that 31.1% Government Schools in normal rate had the infrastructural accessibility while 43.8% Tuition based schools in normal rate had the infrastructural accessibility. Moreover only 22.7% Government Schools provide sports facilities to sports person but on the other hand 50.2% Private schools provide sports facilities to sports person. So the speculation has been acknowledged in light of the fact that the distinction had been seen in sports framework among Government and Non-public schools of Kashmir valley.

[AAJAZ AHMAD BHAT* SUHAIL YAQOOB BHAT. OVERVIEW OF SPORTS INFRASRUCTURE AMONG GOVERNMENT AND PRIVATE SCHOOLS IN  KASHMIR VALLEY. J Am Sci 2023;19(11):19-22]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org  03. doi:10.7537/marsjas191123.03.

Keywords: Government , Private Schools and infrastructure

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SEROPREVALENCE OF SMALL RUMINANT BRUCELLOSIS IN ETHIOPIA: SYSTEMATIC REVIEW AND META-ANALYSIS

Desalegn Zemene¹, Tsegaw Fentie¹, Tsegaye Aseredie², Adem Beyan³

¹ Livestock Resources Development Office Lay Armachiho, Ethiopia. ¹Department of Veterinary Epidemiology and Public Health, College of Veterinary Medicine and Animal Sciences, Gondar, Ethiopia.

² Agricultural Research Institutes, Gondar, Ethiopia.

³ Livestock Resources Development Office Lay Armachiho, Ethiopia. Email:desalegnzemene2008@gmail.com

ABSTRACT: Brucellosis is considered a neglected zoonotic bacterial disease by the  World Health Organization and has been identified as having the highest public health  burden across all sections of the community. The aim of this study is to conduct a  systematic review and Meta analysis on the seroprevalence of small ruminant brucellosis

in Ethiopia. The data searching journal like PubMed, Science Direct, Scopus, Embase an d Google Scholar was used to search the articles. All articles are screened, which was rep orted seroprevalence of small ruminant brucellosis in Ethiopia to be included in the study. Meta-analysis are declared by the effect size by prevalence and standard error of the  prevalence which had been analyzed using random-effects models was used to calculate  the pooled seroprevalence of small ruminant brucellosis in Ethiopia. The estimated  pooled seroprevalence of brucellosis was found to be 3.0% (95% CI: 0.02, 0.03). The sub group analysis showed that there was a statistically significant association between the  disease and study region, publication year, laboratory technique employed and study  years. Also, there was some evidence of publication bias (Egger’s test, p = 0.001) on  studies reporting the prevalence of brucellosis in Ethiopia. This review proves a high  seroprevalence of brucellosis in the country and the need for appropriate intervention  measures, including vaccination and enhanced public awareness, and further surveillance  for the control and prevention of brucellosis in livestock husbandry practices. Further  studies that are aimed at evaluating the risk factors associated with the spread of  brucellosis in domestic animals and sufficient epidemiological data are crucial to the exploration of the epidemiology of the disease throughout the country. 

[Desalegn Zemene, Tsegaw Fentie, Tsegaye Aseredie, Adem Beyan. SEROPREVALENCE OF SMALL RUMINANT BRUCELLOSIS IN ETHIOPIA: SYSTEMATIC REVIEW AND META-ANALYSIS. J Am Sci 2023;19(11):24-32]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org  04. doi:10.7537/marsjas191123.04.

Keywords: Brucellosis, Ethiopia, Meta-analysis, Seroprevalence, Small ruminant

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Big Bang Theory busted by 33 top scientists (May27,2004)...My New Hypothetical Model of Cosmology is true

Gangadhara Rao Irlapati

H.      No.5-30-4/1, Saibabanagar, Jeedimetla, Hyderabad - 500 055, Telangana,  India.

Email: gangadhar19582058@gmail.com

Abstract: There are many theories about the origin, structure, nature and evolution of the cosmos. Every theory is good and also not every theory can be described the universe and could not explain the universe indefinitely. Between 1970_77 years, I have conducted  researches and studies on the origin, structure, nature and evolution of the cosmos and proposed A New Hypothetical Model of Cosmology with hundreds of postulates by taking several facts. On 1^st July 1977 on the basis of those postulates, a book was published in the name of Irlapatism- Irlapati Theory of Universe by supporters. World scientists have done more researches and extensive discussions on my hypothesis and theorize the actual universe and cosmology. In this article I explained how the Big Bang Theory is criticized and how my theory is good.

[Gangadhara Rao Irlapati. Big Bang Theory busted by 33 top scientists (May27,2004)...My New Hypothetical Model of Cosmology is true. J Am Sci 2023;19(11):33-72]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org  05.doi:10.7537/marsjas191123.05.

Key words:  Irlapatism-A New Hypothetical Model of Cosmology, Geo-Universe, Atomic-universe, Photon-universe

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Design of New Future Television Cloud Computing

Salwa M. Serag Eldin

Faculty of computers and Information Technology, Taif University

sserag@gmail.com

Abstract: A design and implementation of new future TV Cloud Computing (ClComp)  for international systems integration and bridging the gap between linear broadcast, information technology and Internet Protocol of television and mobile television is presented to help Authorized Groups (AuthGs) reach and engage audiences on any television screen. . The cloud design is applied to the Egyptian Radio and Television Union (ERTU). The applications, security, efficiency, flexibility, greater agility, less expenditure and to overcome geographic limitations which are the solution of the cloud are introduced to compete in a global market. The design and evaluation steps are addressed to insure the reliability and compatibility of cloud to the desired targets. A software package for audio watermarking has been presented as an example for its application to ensure protection, in case of saving, and security, in case of transmission of the media through the proposed cloud. The package contains many visual tests such as probability, spectrum, power and scatter diagrams to enable user to quickly investigate the content. All this application was done to suit the web–based where many departments can get benefit from anywhere and anytime according to department request and cloud polices.  

[Salwa M. Serag Eldin. Design of New Future Television Cloud Computing. J Am Sci 2023;19(11):73-80]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org  06. doi:10.7537/marsjas191123.06.

Keywords:- AuthGs,  Cloud Computing, ERTU, V-model

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